Estimation of additive effect?

From: Khandker Kislam <kkislam_at_UALBERTA.CA>
Date: Wed, 27 Aug 2008 02:44:24 -0600

Dear Arthur and all,

This is a follow up mail of my previous email entitled "How to get
additive and dominance effect value".

Thanks Arthur for your reply and by using the commands you mentioned I
can get allele substitution effect as well as dominance effect.
(resp ~ mu SNP at(SNP,1) !r animal),
This command gives me both measurement at one single run.

However, still I can't figure out the additive effect which is
estimated as the difference between the two homozygous means divided
by two (Falconer, D. S., and T. F. C. Mackay. 1996. Introduction to
Quantitative Genetics. 4th ed. Longman Scientific and Technical, New
York, NY.). Here, I am using SNP with three genotypes
(0=homozygous,1=heterozygous,2=homozygous), so it will be the estimate
of difference between 0 and 2 divided by 2.

I appreciate your cooperation to solve it.

Best regards,
Graduate Student
University of Alberta
Received on Fri Aug 27 2008 - 02:44:24 EST

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