Re: Binary trait random regression

From: Gustavo A. Gutierrez <ggr03_at_IASTATE.EDU>
Date: Wed, 23 Jan 2008 19:28:28 -0600

Hi Jeff,

We are not the only ones that analyse a female fertility by using random
regression. See the below message sent it to ASReml_list:

> Hello all,
> I have a question regarding the wisdom of fitting a random regression
> model of fecundity (scored as 0 or 1) in a human data set where
> fecundity has been scored annually for several hundred women for each
> year of their life (from 16-50 I think). I have fitted the two models
> below and get apparently sensible results from the second of these in
> which I wanted to test for a genotype by age interaction.
> fec !binary ~ mu fixedFX !r leg(ageS,0).ANIMAL leg(ageS,0).ide(ANIMAL)
> fec !binary ~ mu fixedFX !r leg(ageS,1).ANIMAL leg(ageS,1).ide(ANIMAL
> However, I'm also aware that there are issues relating to the use of
> generalised animal models, and was wondering if anyone had views on
> whether this was valid? Also, if the approach is not inherently wrong,
> is there any way to statistically compare these models if, as I
> understand, the likelihoods should not be used for model comparison.
> Best wishes,
> Alastair
> --
> Alastair J Wilson
> NERC Research Fellow
> tel. 0131 6513608
> Institute of Evolutionary Biology
> School of Biological Sciences
> The University of Edinburgh
> Ashworth Laboratories
> The King's Buildings
> West Mains Road
> Edinburgh EH9 3JT, UK

Gustavo A. Gutierrez
Ph.D. candidate
Animal Breeding and Genetics
Iowa State University
227 Kildee Hall, Ames
phone office:515-2942712
IA 50011-3150
Received on Sat Jan 23 2008 - 19:28:28 EST

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